This drug may be taken with or without food. Safety and efficacy have not been established in patients younger than 18 years.Ĭonsult WARNINGS section for additional precautions. Revatio (R) for the treatment of pulmonary arterial hypertension in elderly patients: Caution is recommended when selecting or adjusting dose in this population. Maximum dose: 25 mg within a 48 hour periodĬoncomitant administration with CYP450 3A4 inhibitors (ketoconazole, itraconazole, saquinavir) or erythromycin: Patients should be stable on alpha blocker therapy prior initiating treatment with this drug.Ĭoncomitant administration with ritonavir: Initial dose: 25 mg orally 1 hour prior to sexual activity Severe hepatic dysfunction (Child-Pugh Class C): Has not been studied Dose AdjustmentsĬoncomitant administration with alpha blockers: Mild to moderate hepatic dysfunction (Child-Pugh Class A and B): No adjustment recommended. Initial dose: 25 mg orally should be considered in patients with any degree of hepatic impairment Severe renal dysfunction (CrCl less than 30 mL/min): 25 mg orally once a day 1 hour prior to sexual activity Mild to moderate renal dysfunction (CrCl 30 to less than 80 mL/min): No adjustment recommended. Use: Treatment of erectile dysfunction Renal Dose Adjustments Initial dose: 25 mg orally once a day 1 hour prior to sexual activity
Use: Treatment of PAH (WHO Group I) in adults to improve exercise ability and delay clinical worsening Usual Geriatric Dose for Erectile Dysfunction A 10 mg injection dose is predicted to provide pharmacological effect equivalent to the 20 mg oral dose. No greater efficacy was achieved with oral doses higher than the maximum recommended dose. Initial dose: 2.5 or 10 mg IV bolus three times a day Maximum dose: 20 mg orally three times a day Initial dose: 5 or 20 mg orally three times a day, 4 to 6 hours apart Use: Treatment of erectile dysfunction Usual Adult Dose for Pulmonary Hypertension Maintenance: 25 to 100 mg orally once a day, as needed, 1 hour prior to sexual activityĬomments: This drug may be taken anywhere from 30 minutes to 4 hours before sexual activity. Initial dose: 50 mg orally once a day, as needed, 1 hour prior to sexual activity Usual Adult Dose for Erectile Dysfunction